The oncogene Musashi1 encodes novel miRNAs in breast cancer
Background: RNA-binding protein Musashi1 (MSI1) shows an increased expression level in several cancers and has been introduced as a prognostic marker in some malignancies. It is expected that if any miRNA is encoded by this gene, it might have a role in cancer development or could be considered as a prognostic biomarker.
2023/12/26
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The effectiveness of extradiagnostic group therapy on the severity of symptoms and disease perception of people with irritable bowel syndrome
Background: The aim of this research was to determine the effectiveness of group therapy on the severity of symptoms and perception of the disease in people with irritable bowel syndrome. The research was a semi-experimental type with a one-month follow-up phase. The population consisted of all female patients suffering from irritable bowel syndrome.
2023/12/26
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Parabens preferentially accumulate in metastatic breast tumors compared to benign breast tumors and the association of breast cancer risk factors with paraben accumulation
Background: Parabens are a category of antimicrobial preservatives that may play a role in the etiology and epidemiology of cancers. Parabens are employed in a wide range of pharmaceuticals, cosmetics, personal care products, andprocessed foods. Parabens are thought to influence the evolution of carcinogenesis in breast cancer by acting as genotoxicants, cell proliferation factors, migratory and metastatic activators, and hyper-accumulate in breast cancer cells.
2023/12/26
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Lynch-like Syndrome and its Molecular Approaches: A Brief Report and Literature Review
Background: Lynch syndrome (LS) predisposes individuals to early-onset colorectal and other Lynch-associated cancer. This disorder is an autosomal dominant genetic disturbance caused by germline mutations in one of the mismatch repair genes. Different clinical and molecular criteria are used to diagnose LS.
2023/12/26
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Lung cancer registry and monitoring: Feasibility study and application (fars lung cancer registry project)
Background: Lung cancer (LC) is the second most common and deadliest cancer in the world. Despite the control of the progressive course of LC in developed countries, studies indicate an increase in the incidence of the disease in developing countries. We designed a stepwise approach‑based surveillance system for registering LC in our region (fars lung cancer registry “FaLCaRe” Project).
2023/12/26
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LncRNA FLVCR1-AS1 functions as competing endogenous RNA (ceRNA) to sponge miR-381-3p and aggravate colorectal cancer via upregulation of Wnt signaling pathway
Background: Colorectal cancer (CRC) is the third most frequent cancer and the second deadliest cancer, worldwide. Long non-coding RNAs (lncRNAs) have been introduced as vital regulators of CRC. lncRNA feline leukemia virus subgroup C receptor 1 antisense RNA 1 (FLVCR1‑AS1) is suggested to play a significant role in the tumorigenesis of several cancers.
2023/12/26
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Human recombinant soluble PD1 can interference in T cells and Treg cells function in response to MDA-MB-231 cancer cell line
Background: PD1/PDL1 pathway targeting using antibodies shows immune related adverse events in patients with tumors. The masking of PD1 ligand by soluble human PD-1 (shPD-1) probably inhibits the PD1/PDL1 interaction between T cells and tumor cells. Accordingly, the goal of this study was to produce human recombinant PD-1-secreting cells and find out how soluble human PD-1 affects T lymphocyte function.
2023/12/26
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Evaluation and comparison of therapeutic effects of probiotics and colloidal bismuth subcitrate on abdominal bloating
Background: Functional abdominal bloating is one of the functional gastrointestinal disorders (FGIDs). Here, we aimed to investigate and compare the effects of probiotics and colloidal bismuth subcitrate on abdominal bloating.
2023/12/26
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Entrepreneurship Development Policies in Iran; A critical Review of the Strategic Document and A Comparison to Alphabet Model of Global Entrepreneurship Monitor
Background: The rapidly changing world, necessitates new demands which forces the governments to change the game in terms of policies to support entrepreneurs to fasten the development of new technologies in response to the needs. The success rates of the policies are monitored and reported by GEM. Iran’s entrepreneurship development indicators have a downward trend in recent years. This study is conducted to analyze the content of Iran's entrepreneurship development policies to uncover the weaknesses for policymaker.
2023/12/26
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Content Analysis of Entrepreneurship and Employment Development Policies in Iran’s Health Sector: Is It a Health Wealth Promoter?
Background: Growing needs mandates economic growth. Entrepreneurship policies play a significant role in achieving productive employment and sustainable development for the health and wealth of society. This study is conducted to find the accordance of this document with the basic theory of the global alphabet model of entrepreneurship on the one hand and a comparison to the real entrepreneurial and economic achievements as social determinants of health (SDOH) on the other hand.
2023/12/26
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CRC-ICM: Colorectal Cancer Immune Cell Markers Pattern Dataset
Background: Colorectal cancer (CRC) is the second most common cause of cancer death in the world, and can be identified by the location of the primary tumor in the large intestine: right and left colon, and rectum. Based on the location, CRC shows differences in chromosomal and molecular characteristics, microbiomes, incidence, pathogenesis, and outcome.
2023/12/26
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Model of Predicting Psychosocial Adaptation to Disease According to Health-Promoting Behaviors with the Mediation Role of Self-Compassion in the Patients with Irritable Bowel Syndrome
Background: The present study was conducted to offer the model of predicting psychosocial adaptation to disease according to health-promoting behaviors with the mediation role of self-compassion in the patients with Irritable Bowel Syndrome (IBS).
2023/8/12
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A Review of Heavy Metals Accumulation in Red Meat and Meat Products in the Middle East
Background: The problem of food contamination is a matter of concern, which can cause health complications in consumers. Several international organizations have created standard permissible limits for heavy metals in meat products. Livestock such as sheep, cattle, camels, and goats are the most important sources of protein meat in the Middle East (ME) countries.
2023/8/12
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Comparing the Effects of Psychodynamic Group Psychotherapy and Mindfulness-Based Stress Reduction on Body Image and Emotional Processing in Patients with Colorectal Cancer
Background: Emotional processing plays an important role in dealing with stress related to chronic diseases. The present study aimed to investigate the effects of psychodynamic group psychotherapy (PGP) and mindfulnessbased stress reduction (MBSR) on body image and emotional processing in patients with colorectal cancer.
2023/8/12
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Comparison of the Effectiveness of Mindfulness Therapy and Interoceptive Exposure on Symptom Severity of Patients with Irritable Bowel Syndrome
Background:Irritable bowel syndrome (IBS) is a debilitating chronic disease due to major changes in the health status and lifestyle of people in recent years; it has been one of the common and significant problems in the field of healthcare and medical professionals, which requires psychological interventions besides the biological treatments due to the accompanying psychological complications. The aim of this study was to compare the effectiveness of mindfulness therapy and interoceptive exposure on symptom severity of patients with IBS.
2023/8/12
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Novel biomarkers for neoplastic progression from ulcerative colitis to colorectal cancer: a systems biology approach
Background: In recent studies, the void of evaluation and in-depth understanding of unknown clinically relevant potential molecular biomarkers involved in colorectal cancer (CRC) from the inflammatory stage of ulcerative colitis (UC) to CRC metastasis, which can be suitable therapeutic targets, is deeply felt. The regulation and interaction among different cancer-promoting molecules, including messenger RNAs (mRNAs) and micro RNAs (miRNAs) in CRC and its progression, were the aim we pursued in this study.
2023/8/12
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Perceived stress, anxiety, and depression in women with breast cancer: CIBC study
Background: Women with breast cancer face elevated risk for psychological problems. We aimed to examine to what extent treatment-naïve women with breast cancer are at higher risk for perceived stress and symptoms of anxiety and depression, compared with matched women with benign breast disease and healthy women, and explore the contribution of perceived stress in the association between breast cancer and symptoms of anxiety and depression.
2023/8/12
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Rescue effect of curcumin against copper toxicity
Background: Turmeric has long been used not only as an indispensable part of Asian cuisine but as a medicinal herb for dressing wounds, bites, burns, treating eye infections and acne. Curcuminoids are the active substances and their synthetic derivatives possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis.
2023/8/12
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The Comparison of the Effectiveness of Trans-diagnostic Treatment and the Acceptance and Commitment Therapy (ACT) on Quality of Life in Patients with Irritable Bowel Syndrome (IBS)
Background: Using new psychological approaches along with biological treatments is an effective measure to reduce secondary mental symptoms caused by biological diseases. The purpose of the present study is to compare the effectiveness of extra diagnostic treatment and treatment based on acceptance and commitment to the quality of life of patients with irritable bowel syndrome.
2023/8/12
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